References

1. Linu M. John, Charlotte M. Dalsgaard, Claus B. Jeppesen, Kilian W. Conde-Frieboes, Katrine Baumann, Niels P. H. Knudsen, Per S. Skov & Birgitte S. Wulff (2021) In vitro prediction of in vivo pseudo-allergenic response via MRGPRX2. Journal of Immunotoxicology, 18:1, 30-36, doi: 10.1080/1547691X.2021.1877375
This paper describes how the human ex vivo microdialysis skin model developed is used to investigate the pseudo-allergic potential of different compounds.

2. Baumann K, Marcelino J, Skov PS, Santos MCP, Wyroslak I, Scheffel J, Altrichter S, Woetmann A, Costa C, Maurer M (2021) Autologous serum skin test reactions in chronic spontaneous urticaria differ from heterologous cell reactions. J Eur Acad Dermatol Venereol, 35(6):1338-1345. doi: 10.1111/jdv.17131.
In this paper, which includes human skin microdialysis, 2 kDa from EP Medical is used.

3. Baumann K, Knudsen NPH, Gadsbøll A-SØ, Woetmann A, Skov PS (2021) Investigating the Early Events after Skin-Barrier Disruption Using Microdialysis—A Human Ex Vivo Skin Model. Dermato, 1(2):47-58. doi: 10.3390/dermato1020008
This paper describes a human microdialysis skin model to investigate the early cutaneous events following a skin trauma using the 3000 kDa probes from EP Medical

4. Kolkhir, P., Elieh-Ali-Komi, D., Metz, M. et al. Understanding human mast cells: lesson from therapies for allergic and non-allergic diseases. Nat Rev Immunol (2021). doi: 10.1038/s41577-021-00622-y
This Nature Review from the expert group at Charité in Berlin recommends the use of skin microdialysate to study therapies for allergic and non-allergic diseases and refer to papers where probes from EP Medical have been used.

5. Klein, A.L.; Lubda, M.; Specht, D.; et al. Microdialysis on Ex Vivo Porchine Ear Skin Can Validly Study Dermal Penetration including the Fraction of Transfollicular Penetration-Demonstrated on Caffeine Nanocrystals. Nanomaterials 2021, 11, 2387 https://doi.org/10.3390/nano 11092387.

6: Baumann KY, Church MK, Clough GF, Quist SR, Schmelz M, Skov PS, Anderson CD, Tannert LK, Giménez-Arnau AM, Frischbutter S, Scheffel J, Maurer M. Skin microdialysis: methods, applications and future opportunities-an EAACI position paper. Clin Transl Allergy. 2019 Apr 10;9:24. doi: 10.1186/s13601-019-0262-y.
eCollection 2019. Review. PubMed PMID: 31007896; PubMed Central PMCID: PMC6456961.

7: Ramirez Molina C, Falkencrone S, Skov PS, Hooper-Greenhill E, Barker M, Dickson MC. GSK2646264, a spleen tyrosine kinase inhibitor, attenuates the release of histamine in ex vivo human skin. Br J Pharmacol. 2019 Apr;176(8):1135-1142. doi: 10.1111/bph.14610. Epub 2019 Mar 21. PubMed PMID: 30735243; PubMed Central PMCID: PMC6451110.

8: Döge N, Hönzke S, Schumacher F, Balzus B, Colombo M, Hadam S, Rancan F, Blume-Peytavi U, Schäfer-Korting M, Schindler A, Rühl E, Skov PS, Church MK, Hedtrich S, Kleuser B, Bodmeier R, Vogt A. Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin – assessment by intradermal microdialysis and extraction from the different skin layers. J Control Release.
2016 Nov 28;242:25-34. doi: 10.1016/j.jconrel.2016.07.009. Epub 2016 Jul 6. PubMed PMID: 27394682.

9: Sjøgren F, Davidson K, Sjøstrøm M, Anderson CD. Cutaneous Microdialysis: Cytokine Evidence for altered innate reactivity in the skin of psoriasis patients?. The AAPS Journal 2012;14:187-195.

10: Petersen LJ, Pedersen JL, Skov PS, Nielsen HJ, Kehlet H. Histamine is not released in acute thermal injury in human skin in vivo: a microdialysis study. Inflamm Res. 2009 Jul;58(7):395-9. doi: 10.1007/s00011-009-0004-z. Epub 2009 6. Mar PubMed PMID: 19266263.

11: Chaurasia CS et al. AAPS-FDA Workshop White Paper: Microdialysis Principles, Application, and Regulatory Perspectives Report From the Joint AAPS-FDA Workshop, November 4-5, 2005, Nashville, TN. The AAPS Journal 2007; 9 (1) Article 6. DOI: 10.1007/s11095-006-9206-z. Source: Pubmed

12: Petersen LJ, Skov PS. No effect of heparin on IgE-dependent and IgE-independent histamine release in human skin in vivo: a microdialysis study. J Dermatol Sci. 2006 Nov;44(2):123-5. Epub 2006 Sep 27. PubMed PMID: 17008062.

13: Petersen LJ, Skov PS. Effect of terbutaline and bambuterol on immediate-type allergic skin responses and mediator release in human skin. Inflamm Res. 2003 Sep;52(9):372-7. PubMed PMID: 14504664.

14: Steinhoff M, Neisius U, Ikoma A, Fartasch M, Heyer G, Skov PS, Luger TA, Schmelz M. Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci. 2003 Jul 16;23(15):6176-80. PubMed PMID: 12867500.

15: Petersen LJ, Skov PS. The effect of salmeterol and salbutamol on mediator release and skin responses in immediate and late phase allergic cutaneous reactions. Inflamm Res. 1999 Oct;48(10):527-32. PubMed PMID: 10563469.

16: Petersen LJ, Church MK, Rihoux JP, Skov PS. Measurement of interstitial cetirizine concentrations in human skin: correlation of drug levels with inhibition of histamine-induced skin responses. Allergy. 1999 Jun;54(6):607-11. PubMed PMID: 10435475.

17: Odum L, Petersen LJ, Skov PS, Ebskov LB. Pituitary adenylate cyclase activating polypeptide (PACAP) is localized in human dermal neurons and causes histamine release from skin mast cells. Inflamm Res. 1998 Dec;47(12):488-92. PubMed PMID: 9892043.

18. Petersen LJ, Winge K, Brodin E, Skov PS. No release of histamine and substance P in capsaicin-induced neurogenic inflammation in intact human skin in vivo: a microdialysis study. Clin Exp Allergy. 1997 Aug;27(8):957-65. PubMed PMID: 9291295.

19: Petersen LJ, Church MK, Skov PS. Platelet-activating factor induces histamine release from human skin mast cells in vivo, which is reduced by local nerve blockade. J Allergy Clin Immunol. 1997 May;99(5):640-7. PubMed PMID: 9155831.

20: Petersen LJ, Church MK, Skov PS. Histamine is released in the wheal but not the flare following challenge of human skin in vivo: a microdialysis study. Clin Exp Allergy. 1997 Mar;27(3):284-95. PubMed PMID: 9088655.

21: Petersen LJ, Brasso K, Pryds M, Skov PS. Histamine release in intact human skin by monocyte chemoattractant factor-1, RANTES, macrophage inflammatory protein-1 alpha, stem cell factor, anti-IgE, and codeine as determined by an ex vivo skin microdialysis technique. J Allergy Clin Immunol. 1996 Oct;98(4):790-6. PubMed PMID: 8876555.

22: Petersen LJ, Mosbech H, Skov PS. Allergen-induced histamine release in intact human skin in vivo assessed by skin microdialysis technique: characterization of factors influencing histamine releasability. J Allergy Clin Immunol. 1996 Feb;97(2):672-9. PubMed PMID: 8621853.

23: Petersen LJ, Skov PS. Methacholine induces wheal-and-flare reactions in human skin but does not release histamine in vivo as assessed by the skin microdialysis technique. Allergy. 1995 Dec;50(12):976-80. PubMed PMID: 8834827.

24: Petersen LJ, Nielsen HJ, Skov PS. Codeine-induced histamine release in intact human skin monitored by skin microdialysis technique: comparison of intradermal injections with an atraumatic intraprobe drug delivery system. Clin Exp Allergy. 1995 Nov;25(11):1045-52. PubMed PMID: 8581836.

25: Petersen LJ, Skov PS, Bindslev-Jensen C, Søndergaard J. Histamine release in immediate-type hypersensitivity reactions in intact human skin measured by microdialysis. A preliminary study. Allergy. 1992 Dec;47(6):635-7. PubMed PMID: 1283659.