New! Application of EP Medical probes on ex vivo microdialysis on human skin

In a recent publication, EP Medical microdialysis probes (EP Ultra High Flux Probes 3000 kDa molecular weight cutoff) were used in an ex vivo human skin model. The aim of the study was to identify potent and selective antagonists to pharmacologically characterize the role of MGPRX2 in relevant in vitro, ex vivo and in vivo models. The ex vivo human skin microdialysis model using EP Medical probes was an important part of the study and supported the investigation of MRgPRX2 receptor antagonists in mast cell-driven allergic skin disorders such as chronic spontaneous urticaria.

Reference: Macphee CH, Dong X, Peng Q, Paone DV, Skov PS, Baumann K, Roethke T, Goldspink DA, Pearson SK and Wu Z (2024)
Pharmacological blockade of the mast cell MRGPRX2 receptor supports investigation of its relevance in skin disorders.
Front. Immunol. 15:1433982. doi: 10.3389/fimmu.2024.1433982