Application of EP Medical probes on Ex Vivo microdialysis on Porchine ear skin.

In a recent study microdialysis was applied on ex vivo porchine ear skin using 2 kDa microdialysis probes from EP Medical. The study demonstrated that dermal penetration could be validly demonstrated including the fraction of transfollicular penetration – demonstrated on caffeine nanocrystals. The authors conclude:

“Microdialysis performed on ex vivo porchine ear skin is a novel experimental set up. It is of high interest for further investigations since it is able also to capture the impact of follicular and transfollicular penetration kinetics as no other ex vivo setup can.”

Reference. Klein, A.L.; Lubda, M.; Specht, D.; et al. Microdialysis on Ex Vivo Porchine Ear Skin Can Validly Study Dermal Penetration including the Fraction of Transfollicular Penetration-Demonstrated on Caffeine Nanocrystals. Nanomaterials 2021, 11, 2387. https://doi.org/10.3390/nano 11092387.